Current concepts in combination antibiotic therapy for critically ill patients

被引：70

作者：

Ahmed, Armin ^{[1
]}

Azim, Afzal ^{[1
]}

Gurjar, Mohan ^{[1
]}

Baronia, Arvind Kumar ^{[1
]}

机构：

[1] Sanjay Gandhi Postgrad Inst Med Sci, Dept Crit Care Med, Lucknow 226014, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF CRITICAL CARE MEDICINE | 2014年 / 18卷 / 05期

关键词：

Carbapenem-resistant enterobacteriaceae; combination antibiotic therapy; Klebsiella pneumoniae carbapenemase; sepsis;

D O I：

10.4103/0972-5229.132495

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Widespread emergence of multidrug resistant (MDR) bacterial pathogens is a problem of global dimension. MDR infections are difficult to treat and frequently associated with high mortality. More than one antibiotic is commonly used to treat such infections, but scientific evidence does not favor use of combination therapy in most cases. However, there are certain subgroups where combination therapy may be beneficial, e.g. sepsis due to carbapenem-resistant Enterobacteriaceae (CRE), bacteremic pneumococcal pneumonia, and patients with multiple organ failure. Well-designed prospective studies are needed to clearly define the role of combination therapy in these subgroups.

引用

页码：310 / 314

页数：5

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