Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention

被引：780

作者：

Gupta, Neil ^{[1
,2
]}

Limbago, Brandi M. ^{[1
]}

Patel, Jean B. ^{[1
]}

Kallen, Alexander J. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA

[2] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 53卷 / 01期

关键词：

KLEBSIELLA-PNEUMONIAE CARBAPENEMASE; METALLO-BETA-LACTAMASE; INTENSIVE-CARE-UNIT; IMIPENEM RESISTANCE; K; PNEUMONIAE; EMERGENCE; OUTBREAK; INFECTION; STRAIN; IMPACT;

D O I：

10.1093/cid/cir202

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Over the past 10 years, dissemination of Klebsiella pneumoniae carbapenemase (KPC) has led to an increase in the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Infections caused by CRE have limited treatment options and have been associated with high mortality rates. In the previous year, other carbapenemase subtypes, including New Delhi metallo-beta-lactamase, have been identified among Enterobacteriaceae in the United States. Like KPC, these enzymes are frequently found on mobile genetic elements and have the potential to spread widely. As a result, preventing both CRE transmission and CRE infections have become important public health objectives. This review describes the current epidemiology of CRE in the United States and highlights important prevention strategies.

引用

页码：60 / 67

页数：8

共 48 条

[1] Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobactetiaceae [J].

Anderson, K. F. ;

Lonsway, D. R. ;

Rasheed, J. K. ;

Biddle, J. ;

Jensen, B. ;

McDougal, L. K. ;

Carey, R. B. ;

Thompson, A. ;

Stocker, S. ;

Limbago, B. ;

Patel, J. B. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (08) :2723-2725

[2] Potential Role of Active Surveillance in the Control of a Hospital-Wide Outbreak of Carbapenem-Resistant Klebsiella pneumoniae Infection [J].

Ben-David, Debby ;

Maor, Yasmin ;

Keller, Nathan ;

Regev-Yochay, Gili ;

Tal, Ilana ;

Shachar, Dalit ;

Zlotkin, Amir ;

Smollan, Gill ;

Rahav, Galia .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2010, 31 (06) :620-626

[3] How to stem the tide of carbapenemase-producing Enterobacteriaceae?: proactive versus reactive strategies [J].

Bilavsky, Efraim ;

Schwaber, Mitchell J. ;

Carmeli, Yehuda .

CURRENT OPINION IN INFECTIOUS DISEASES, 2010, 23 (04) :327-331

[4] Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the loss of an outer membrane protein [J].

Bradford, PA ;

Urban, C ;

Mariano, N ;

Projan, SJ ;

Rahal, JJ ;

Bush, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (03) :563-569

[5] Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City -: A new threat to our antibiotic armamentarium [J].

Bratu, S ;

Landman, D ;

Haag, R ;

Recco, R ;

Eramo, A ;

Alam, M ;

Quale, J .

ARCHIVES OF INTERNAL MEDICINE, 2005, 165 (12) :1430-1435

[6] Detection and spread of Escherichia coli possessing the plasmid-borne carbapenemase KPC-2 in Brooklyn, New York [J].

Bratu, Simona ;

Brooks, Steven ;

Burney, Sibte ;

Kochar, Sandeep ;

Gupta, Jyoti ;

Landman, David ;

Quale, John .

CLINICAL INFECTIOUS DISEASES, 2007, 44 (07) :972-975

[7] The Inguinal Skin: An Important Site of Colonization with Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae [J].

Buehlmann, Manuela ;

Fankhauser, Hans ;

Laffer, Reto ;

Bregenzer, Thomas ;

Widmer, Andreas F. .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2010, 31 (04) :427-428

[8] Use of Active Surveillance Cultures to Detect Asymptomatic Colonization With Carbapenem-Resistant Klebsiella pneumoniae in Intensive Care Unit Patients [J].

Calfee, David ;

Jenkins, Stephen G. .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2008, 29 (10) :966-968

[9] Antimicrobial Susceptibility Patterns of KPC-Producing or CTX-M-Producing Enterobacteriaceae [J].

Castanheira, Mariana ;

Sader, Helio S. ;

Jones, Ronald N. .

MICROBIAL DRUG RESISTANCE, 2010, 16 (01) :61-65

[10] IMIPENEM RESISTANCE ASSOCIATED WITH THE LOSS OF A 40 KDA OUTER-MEMBRANE PROTEIN IN ENTEROBACTER-AEROGENES [J].

CHOW, JW ;

SHLAES, DM .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1991, 28 (04) :499-504

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