Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention

被引：780

作者：

Gupta, Neil ^{[1
,2
]}

Limbago, Brandi M. ^{[1
]}

Patel, Jean B. ^{[1
]}

Kallen, Alexander J. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA

[2] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 53卷 / 01期

关键词：

KLEBSIELLA-PNEUMONIAE CARBAPENEMASE; METALLO-BETA-LACTAMASE; INTENSIVE-CARE-UNIT; IMIPENEM RESISTANCE; K; PNEUMONIAE; EMERGENCE; OUTBREAK; INFECTION; STRAIN; IMPACT;

D O I：

10.1093/cid/cir202

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Over the past 10 years, dissemination of Klebsiella pneumoniae carbapenemase (KPC) has led to an increase in the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Infections caused by CRE have limited treatment options and have been associated with high mortality rates. In the previous year, other carbapenemase subtypes, including New Delhi metallo-beta-lactamase, have been identified among Enterobacteriaceae in the United States. Like KPC, these enzymes are frequently found on mobile genetic elements and have the potential to spread widely. As a result, preventing both CRE transmission and CRE infections have become important public health objectives. This review describes the current epidemiology of CRE in the United States and highlights important prevention strategies.

引用

页码：60 / 67

页数：8

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