RETINOIC ACID, A DEVELOPMENTAL SIGNALING MOLECULE

被引：138

作者：

SUMMERBELL, D ^{[1
]}

MADEN, M ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL,DEPT ANAT,LONDON WC2R 2LS,ENGLAND

来源：

TRENDS IN NEUROSCIENCES | 1990年 / 13卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0166-2236(90)90006-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Retinoic acid has been used as a tool both by embryologists studying the spatial organization of cells in the embryo and by molecular biologists studying the control of gene expression in the nucleus. Embryologists have shown that retinoic acid can modify the pattern of cell differentiation so as to duplicate complete parts of the embryo in a well-organized way; molecular biologists have shown that retinoic acid can act as the switch starting the sequence of differential gene expression that results in cell differentiation. In the past year these two approaches have converged so that there now seems a real possibility that we may soon for the first time understand how a particular vertebrate development system works. © 1990.

引用

页码：142 / 147

页数：6

共 40 条

[1]

BELL KM, 1985, J EMBRYOL EXP MORPH, V86, P219

[2] A NEW RETINOIC ACID RECEPTOR IDENTIFIED FROM A HEPATOCELLULAR-CARCINOMA [J].

BENBROOK, D ;

LERNHARDT, E ;

PFAHL, M .

NATURE, 1988, 333 (6174) :669-672

[3] IDENTIFICATION OF A 2ND HUMAN RETINOIC ACID RECEPTOR [J].

BRAND, N ;

PETKOVICH, M ;

KRUST, A ;

CHAMBON, P ;

DETHE, H ;

MARCHIO, A ;

TIOLLAIS, P ;

DEJEAN, A .

NATURE, 1988, 332 (6167) :850-853

[4]

CHILD CM, 1941, PATTERNS PROBLEMS DE

[5]

COOKE J, 1987, DEVELOPMENT, V101, P893

[6] CELL-CYCLE AND EXPERIMENTAL PATTERN DUPLICATION IN THE CHICK WING DURING EMBRYONIC-DEVELOPMENT [J].

COOKE, J ;

SUMMERBELL, D .

NATURE, 1980, 287 (5784) :697-701

[7]

Dhouailly D, 1982, Prog Clin Biol Res, V85 Pt B, P309

[8] THE STEROID AND THYROID-HORMONE RECEPTOR SUPERFAMILY [J].

EVANS, RM .

SCIENCE, 1988, 240 (4854) :889-895

[9] IDENTIFICATION OF A RECEPTOR FOR THE MORPHOGEN RETINOIC ACID [J].

GIGUERE, V ;

ONG, ES ;

SEGUI, P ;

EVANS, RM .

NATURE, 1987, 330 (6149) :624-629

[10] SPATIAL AND TEMPORAL EXPRESSION OF THE RETINOIC ACID RECEPTOR IN THE REGENERATING AMPHIBIAN LIMB [J].

GIGUERE, V ;

ONG, ES ;

EVANS, RM ;

TABIN, CJ .

NATURE, 1989, 337 (6207) :566-569

← 1 2 3 4 →