RETINOIC ACID, A DEVELOPMENTAL SIGNALING MOLECULE

被引：138

作者：

SUMMERBELL, D ^{[1
]}

MADEN, M ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL,DEPT ANAT,LONDON WC2R 2LS,ENGLAND

来源：

TRENDS IN NEUROSCIENCES | 1990年 / 13卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0166-2236(90)90006-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Retinoic acid has been used as a tool both by embryologists studying the spatial organization of cells in the embryo and by molecular biologists studying the control of gene expression in the nucleus. Embryologists have shown that retinoic acid can modify the pattern of cell differentiation so as to duplicate complete parts of the embryo in a well-organized way; molecular biologists have shown that retinoic acid can act as the switch starting the sequence of differential gene expression that results in cell differentiation. In the past year these two approaches have converged so that there now seems a real possibility that we may soon for the first time understand how a particular vertebrate development system works. © 1990.

引用

页码：142 / 147

页数：6

共 40 条

[11] NUCLEAR RECEPTORS ENHANCE OUR UNDERSTANDING OF TRANSCRIPTION REGULATION [J].

GREEN, S ;

CHAMBON, P .

TRENDS IN GENETICS, 1988, 4 (11) :309-314

[12]

Huxley J.S., 1934, ELEMENTS EXPT EMBRYO

[13] RETINOIC ACID-BINDING PROTEIN IN THE AXOLOT - DISTRIBUTION IN MATURE TISSUES AND TIME OF APPEARANCE DURING LIMB REGENERATION [J].

KEEBLE, S ;

MADEN, M .

DEVELOPMENTAL BIOLOGY, 1986, 117 (02) :435-441

[14]

KOCHHAR DM, 1967, ACTA PATHOL MIC SC, V70, P398

[15]

MADEN M, 1986, J EMBRYOL EXP MORPH, V97, P239

[16] SPATIAL-DISTRIBUTION OF CELLULAR PROTEIN-BINDING TO RETINOIC ACID IN THE CHICK LIMB BUD [J].

MADEN, M ;

ONG, DE ;

SUMMERBELL, D ;

CHYTIL, F .

NATURE, 1988, 335 (6192) :733-735

[17] VITAMIN-A AND PATTERN-FORMATION IN THE REGENERATING LIMB [J].

MADEN, M .

NATURE, 1982, 295 (5851) :672-675

[18]

MADEN M, 1983, J EMBRYOL EXP MORPH, V77, P273

[19] THE EFFECT OF VITAMIN-A ON LIMB REGENERATION IN RANA-TEMPORARIA [J].

MADEN, M .

DEVELOPMENTAL BIOLOGY, 1983, 98 (02) :409-416

[20] ACTIVATION OF 4 HOMEOBOX GENE CLUSTERS IN HUMAN EMBRYONAL CARCINOMA-CELLS INDUCED TO DIFFERENTIATE BY RETINOIC ACID [J].

MAVILIO, F ;

SIMEONE, A ;

BONCINELLI, E ;

ANDREWS, PW .

DIFFERENTIATION, 1988, 37 (01) :73-79

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