FREQUENCY OF DELETION FORMATION DECREASES EXPONENTIALLY WITH DISTANCE BETWEEN SHORT DIRECT REPEATS

被引：74

作者：

CHEDIN, F ^{[1
]}

DERVYN, E ^{[1
]}

DERVYN, R ^{[1
]}

EHRLICH, SD ^{[1
]}

NOIROT, P ^{[1
]}

机构：

[1] INRA, GENET MICROBIENNE LAB, F-78352 JOUY EN JOSAS, FRANCE

来源：

MOLECULAR MICROBIOLOGY | 1994年 / 12卷 / 04期

关键词：

D O I：

10.1111/j.1365-2958.1994.tb01042.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of distance between 18 bp direct repeats on deletion formation has been examined in Bacillus subtilis. The deletion frequency decreased exponentially by more than 1000-fold as the distance increased from 33 to 2313 bp. This decrease occurred in two distinct phases, which may be determined by DNA-duplex flexibility A similar relationship between deletion formation and distance was observed in a theta-replicating plasmid and in the chromosome, indicating that this relationship might have a general validity.

引用

页码：561 / 569

页数：9

共 59 条

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