ENDOTHELINS AND SARAFOTOXINS - PHYSIOLOGICAL REGULATION, RECEPTOR SUBTYPES AND TRANSMEMBRANE SIGNALING

被引：60

作者：

SOKOLOVSKY, M

机构：

[1] M. Sokolovsky is at the Laboratory of Neurobiochemistry, Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 07期

关键词：

D O I：

10.1016/0968-0004(91)90100-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The endothelins and sarafotoxins are two structurally related families of potent vasoactive peptides. Although the exact physiological function of these peptides is not known, the endothelins are probably involved in pathophysiological conditions such as hypertension and heart failure. This article will review the biochemistry of these peptides and their receptors, with special reference to proteolytic regulation, receptor subtypes and the G protein-linked phosphoinositide signal transduction pathway.

引用

页码：261 / 264

页数：4

共 32 条

[1] CROSS-LINKING OF ENDOTHELIN-1 AND ENDOTHELIN-3 TO RAT-BRAIN MEMBRANES - IDENTIFICATION OF THE PUTATIVE RECEPTOR(S)
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[2] CLONING AND EXPRESSION OF A CDNA-ENCODING AN ENDOTHELIN RECEPTOR
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[3] DISTURBANCES IN THE CARDIOVASCULAR-SYSTEM CAUSED BY ENDOTHELIN AND SARAFOTOXIN
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[5] NEUTRAL ENDOPEPTIDASE 24.11 (ENKEPHALINASE) AND RELATED REGULATORS OF PEPTIDE-HORMONES
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[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 171 (03) : 949 - 954
[7] GALRON R, IN PRESS FEBS LETT
[8] INTERACTION OF SYNTHETIC SARAFOTOXIN WITH RAT VASCULAR ENDOTHELIN RECEPTORS
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[9] STRUCTURE-ACTIVITY-RELATIONSHIPS OF ENDOTHELIN - IMPORTANCE OF THE C-TERMINAL MOIETY
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[10] 3 APPARENT RECEPTOR SUBTYPES FOR THE ENDOTHELIN SARAFOTOXIN FAMILY
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BOUSSOMITTLER, D
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[J]. FEBS LETTERS, 1989, 253 (1-2): : 199 - 202

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