THE ANTI-HIV ACTIVITY OF THE PHYTOCHEMICAL ALPHA-TERTHIENYL

被引：30

作者：

HUDSON, JB

HARRIS, L

TEEPLE, A

TOWERS, GHN

机构：

[1] UNIV BRITISH COLUMBIA,BC PROV AIDS LAB,VANCOUVER V5Z 1M9,BC,CANADA

[2] UNIV BRITISH COLUMBIA,DEPT BOT,VANCOUVER V5Z 1M9,BC,CANADA

来源：

ANTIVIRAL RESEARCH | 1993年 / 20卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ANTI-HIV ACTIVITY; ALPHA-TERTHIENYL; PHYTOCHEMICAL;

D O I：

10.1016/0166-3542(93)90057-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The plant trithiophene, alpha-terthienyl (alphaT), was evaluated for activity against the human immunodeficiency virus (HIV-1). Antiviral activity specifically required long wavelength light (UVA, 320-400 nm). The compound had little or no activity in visible light or in the dark. The anti-HIV effect was UVA-dose dependent and was proportional to the concentration of alphaT, according to several parameters of virus infectivity and replication. The efficacy was decreased to some extent by the presence of bovine serum in the reactions; but under optimal conditions 0.1 mug/ml. alphaT (3 x 10(-7) M) could inactivate 10(4)-10(5) infectious particles. In contrast poliovirus and Coxsackievirus infectivity were relatively resistant to alphaT + UVA.

引用

页码：33 / 43

页数：11

共 30 条

[1] ALTERNATIVE THERAPIES IN HIV-INFECTION [J].