IMMUNIZATION WITH NONSTRUCTURAL PROTEINS E1 AND E2 OF COTTONTAIL RABBIT PAPILLOMAVIRUS STIMULATES REGRESSION OF VIRUS-INDUCED PAPILLOMAS

被引：82

作者：

SELVAKUMAR, R

BORENSTEIN, LA

LIN, YL

AHMED, R

WETTSTEIN, FO

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, DEPT MICROBIOL & IMMUNOL, LOS ANGELES, CA 90024 USA

[2] UNIV CALIF LOS ANGELES, SCH MED, JONSSON COMPREHENS CANC CTR, LOS ANGELES, CA 90024 USA

[3] UNIV CALIF LOS ANGELES, SCH MED, INST MOLEC BIOL, LOS ANGELES, CA 90024 USA

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 01期

关键词：

D O I：

10.1128/JVI.69.1.602-605.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cottontail rabbit papillomavirus is the major animal model for cancer-associated papillomaviruses. Here we show that vaccination with the nonstructural proteins El and E2 induces the regression of virus-induced papillomas and that vaccination is equally effective when proteins are given with and without adjuvant. There was no correlation between antibody levels and regression, suggesting that tumor regression may be due to a cell-mediated response.

引用

页码：602 / 605

页数：4

共 32 条

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