IMMUNE-RESPONSE TO HUMAN PAPILLOMAVIRUS TYPE-16 E6 GENE IN A LIVE VACCINIA VECTOR

被引:50
作者
GAO, L
CHAIN, B
SINCLAIR, C
CRAWFORD, L
ZHOU, J
MORRIS, J
ZHU, X
STAUSS, H
机构
[1] UCL, DEPT BIOL, ICRF, PAPILLOMAVIRUS GRP, LONDON WC1E 6BT, ENGLAND
[2] UNIV CAMBRIDGE, ICRF, DEPT PATHOL, TUMOR VIRUS GRP, CAMBRIDGE CB2 1QP, CAMBS, ENGLAND
[3] UNIV QUEENSLAND, PRINCESS ALEXANDRA HOSP, LIONS HUMAN IMMUNOL LABS, PAPILLOMAVIRUS RES UNIT, WOOLLOONGABBA, QLD 4102, AUSTRALIA
[4] ST MARYS HOSP, SCH MED, LUDWIG INST CANC RES, LONDON W2 1PG, ENGLAND
[5] ICRF, COURTLAND INST BIOCHEM, HUMAN TUMOR IMMUNOL GRP, LONDON W1P 8PT, ENGLAND
关键词
D O I
10.1099/0022-1317-75-1-157
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Immunization of mice with a recombinant vaccinia virus expressing the human papillomavirus type 16 (HPV-16) E6 gene elicits specific antibody, proliferative and cytotoxic T lymphocyte responses. T and B cell epitopes were mapped by using synthetic peptides. This study provides the background to future investigation aimed at developing prophylactic and therapeutic vaccines against HPV-16 infection and cervical cancer.
引用
收藏
页码:157 / 164
页数:8
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