IMMUNE-RESPONSE TO HUMAN PAPILLOMAVIRUS TYPE-16 E6 GENE IN A LIVE VACCINIA VECTOR

被引：50

作者：

GAO, L

CHAIN, B

SINCLAIR, C

CRAWFORD, L

ZHOU, J

MORRIS, J

ZHU, X

STAUSS, H

机构：

[1] UCL, DEPT BIOL, ICRF, PAPILLOMAVIRUS GRP, LONDON WC1E 6BT, ENGLAND

[2] UNIV CAMBRIDGE, ICRF, DEPT PATHOL, TUMOR VIRUS GRP, CAMBRIDGE CB2 1QP, CAMBS, ENGLAND

[3] UNIV QUEENSLAND, PRINCESS ALEXANDRA HOSP, LIONS HUMAN IMMUNOL LABS, PAPILLOMAVIRUS RES UNIT, WOOLLOONGABBA, QLD 4102, AUSTRALIA

[4] ST MARYS HOSP, SCH MED, LUDWIG INST CANC RES, LONDON W2 1PG, ENGLAND

[5] ICRF, COURTLAND INST BIOCHEM, HUMAN TUMOR IMMUNOL GRP, LONDON W1P 8PT, ENGLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1994年 / 75卷

关键词：

D O I：

10.1099/0022-1317-75-1-157

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Immunization of mice with a recombinant vaccinia virus expressing the human papillomavirus type 16 (HPV-16) E6 gene elicits specific antibody, proliferative and cytotoxic T lymphocyte responses. T and B cell epitopes were mapped by using synthetic peptides. This study provides the background to future investigation aimed at developing prophylactic and therapeutic vaccines against HPV-16 infection and cervical cancer.

引用

页码：157 / 164

页数：8

共 29 条

[1] THE SMALLPOX STORY - LIFE AND DEATH OF AN OLD DISEASE [J].