POWERFUL HEPATOPROTECTIVE AND HEPATOTOXIC PLANT OLIGOSTILBENES, ISOLATED FROM THE ORIENTAL MEDICINAL PLANT VITIS-COIGNETIAE (VITACEAE)

被引：75

作者：

OSHIMA, Y

NAMAO, K

KAMIJOU, A

MATSUOKA, S

NAKANO, M

TERAO, K

OHIZUMI, Y

机构：

[1] TOHOKU UNIV, INST PHARMACEUT, DEPT PHARMACEUT MOLEC BIOL, AOBA KU, SENDAI, MIYAGI 980, JAPAN

[2] CHIBA UNIV, PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR, CHIBA 280, JAPAN

来源：

EXPERIENTIA | 1995年 / 51卷 / 01期

关键词：

VITACEAE; VITIS COIGNETIAE; HEPATOPROTECTIVE SUBSTANCE; OLIGOSTILBENE; HEPATOTOXIN;

D O I：

10.1007/BF01964921

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The methanol extract of the Oriental medicinal plant Vitis coignetiae (Vitaceae) showed hepatoprotective activity in the in vitro assay method using primary cultured rat hepatocytes. Activity-guided fractionation of the extract afforded epsilon-viniferin as an active principle. The protective effect of epsilon-viniferin against mice carbon tetrachloride-induced hepatic injury in mice was shown by serum enzyme assay as well as by pathological examination. In addition to epsilon-viniferin, plant oligostilbenes, ampelopsins A, C, F and the mixture of vitisin A and cis-vitisin A were also present in the extract. Among them, ampelopsin C and the mixture of vitisin A and cis-vitisin A were found to be powerful hepatotoxins.

引用

页码：63 / 66

页数：4

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