INHIBITION OF RAINBOW-TROUT PHAGOCYTE RESPONSIVENESS TO HUMAN TUMOR-NECROSIS-FACTOR-ALPHA (HTNF-ALPHA) WITH MONOCLONAL-ANTIBODIES TO THE HTNF-ALPHA 55-KDA RECEPTOR

被引：24

作者：

JANG, SI ^{[1
]}

MULERO, V ^{[1
]}

HARDIE, LJ ^{[1
]}

SECOMBES, CJ ^{[1
]}

机构：

[1] UNIV ABERDEEN,DEPT ZOOL,TILLYDRONE AVE,ABERDEEN AB9 2TN,SCOTLAND

来源：

FISH & SHELLFISH IMMUNOLOGY | 1995年 / 5卷 / 01期

关键词：

TUMOR NECROSIS FACTOR-ALPHA; TUMOR NECROSIS FACTOR-ALPHA RECEPTOR; RAINBOW TROUT; PHAGOCYTES; MIGRATION; RESPIRATORY BURST; MONOCLONAL ANTIBODIES;

D O I：

10.1016/S1050-4648(05)80007-5

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Human tumor necrosis factor a (hTNFa) was found to increase rainbow trout macrophage respiratory burst activity and neutrophil migration. The increase in respiratory burst activity was inhibited by preincubation of the hTNFa with a soluble 55 kDa hTNFa receptor (TNF-R1). Preincubation of the phagocytes with monoclonal antibodies (MAbs) to the TNF-R1 was found to ablate their responsiveness to hTNFa, dependent on the concentration of MAbs used. These findings are discussed with a view towards using such MAbs to elucidate the possible secretion of TNF by fish leucocytes.

引用

页码：61 / 69

页数：9

共 22 条

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