INHIBITION OF RAINBOW-TROUT PHAGOCYTE RESPONSIVENESS TO HUMAN TUMOR-NECROSIS-FACTOR-ALPHA (HTNF-ALPHA) WITH MONOCLONAL-ANTIBODIES TO THE HTNF-ALPHA 55-KDA RECEPTOR

被引：24

作者：

JANG, SI ^{[1
]}

MULERO, V ^{[1
]}

HARDIE, LJ ^{[1
]}

SECOMBES, CJ ^{[1
]}

机构：

[1] UNIV ABERDEEN,DEPT ZOOL,TILLYDRONE AVE,ABERDEEN AB9 2TN,SCOTLAND

来源：

FISH & SHELLFISH IMMUNOLOGY | 1995年 / 5卷 / 01期

关键词：

TUMOR NECROSIS FACTOR-ALPHA; TUMOR NECROSIS FACTOR-ALPHA RECEPTOR; RAINBOW TROUT; PHAGOCYTES; MIGRATION; RESPIRATORY BURST; MONOCLONAL ANTIBODIES;

D O I：

10.1016/S1050-4648(05)80007-5

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Human tumor necrosis factor a (hTNFa) was found to increase rainbow trout macrophage respiratory burst activity and neutrophil migration. The increase in respiratory burst activity was inhibited by preincubation of the hTNFa with a soluble 55 kDa hTNFa receptor (TNF-R1). Preincubation of the phagocytes with monoclonal antibodies (MAbs) to the TNF-R1 was found to ablate their responsiveness to hTNFa, dependent on the concentration of MAbs used. These findings are discussed with a view towards using such MAbs to elucidate the possible secretion of TNF by fish leucocytes.

引用

页码：61 / 69

页数：9

共 22 条

[11]

Lewis, Tartaglia, Lee, Bennett, Rice, Wong, Chen, Goeddel, Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific, Proceedings of the National Academy of Science, USA, 88, pp. 2830-2834, (1991)

[12]

Newman, Wilkinson, Chemotactic activity of lymphotoxin and tumor necrosis factor alpha for human neutrophils, Immunology, 66, pp. 318-320, (1989)

[13]

Ozaki, Ohashi, Niwa, Kume, Effect of recombinant DNA-produced tumor necrosis factor on various parameters of neutrophil function, Inflammation, 12, pp. 297-309, (1988)

[14]

Pick, Microassays for superoxide and hydrogen peroxide production and nitroblue tetrazolium reduction using an enzyme immunoassay microplate reader, Methods in Enzymology, 132, pp. 407-421, (1986)

[15]

Secombes, Isolation of salmonid macrophages and analysis of their killing activity, Techniques in Fish Immunology, pp. 137-154, (1990)

[16]

Sharp, Pike, Secombes, Leucocyte migration in rainbow trout (Oncorhynchus mykiss [Walbaum]): Optimisation of migration conditions and responses to host and pathogen(Diphyllobothrium dendriticum [Nitzsch]) derived chemoattractants, Developmental and Comparative Immunology, 15, pp. 295-305, (1991)

[17]

Tartaglia, Goeddel, Two TNF receptors, Immunology Today, 13, pp. 151-153, (1992)

[18]

Thomson, The cytokine handbook, (1991)

[19]

Von Asmuth, Leeuwenberg, van der Linden, Buurman, Tumour necrosis factor-a induces neutrophil-mediated injury of cultured human endothelial cells, Scandinavian Journal of Immunology, 34, pp. 197-206, (1991)

[20]

Wang, Bersani, Mantovani, Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes, Journal of Immunology, 138, pp. 1469-1474, (1987)

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