NOREPINEPHRINE EVOKES A MARKED MG-2+ EFFLUX FROM LIVER-CELLS

被引：68

作者：

ROMANI, A

SCARPA, A

机构：

[1] Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland

来源：

FEBS LETTERS | 1990年 / 269卷 / 01期

关键词：

Hepatocyte; Mg[!sup]2+[!/sup; Rat liver; β-Adrenergic receptor; cAMP;

D O I：

10.1016/0014-5793(90)81113-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The addition of norepinephrine to perfused rat livers and to collagenase isolated hepatocytes induced a marked and dose-dependent magnesium efflux. The addition of β-adrenergic receptor antagonists, but not α-antagonists, completely blocked the Mg2+ efflux. The Mg2+ efflux could also be induced by forskolin and by permeable cAMP analogues. By contrast, the addition of carbachol or vasopressin induced a Mg2+ influx into isolated hepatocytes. These results indicate that a significant Mg2+ efflux from liver cells can be induced through the β-adrenergic receptors and that it is mediated through the cytosolic cAMP levels. © 1990.

引用

页码：37 / 40

页数：4