A REINVESTIGATION OF THE TAXOL CONTENT OF HIMALAYAN TAXUS-WALLICHIANA ZUCC AND A REVISION OF THE STRUCTURE OF BREVIFOLIOL

被引：35

作者：

GEORG, GI ^{[1
]}

GOLLAPUDI, SR ^{[1
]}

GRUNEWALD, GL ^{[1
]}

GUNN, CW ^{[1
]}

HIMES, RH ^{[1
]}

RAO, BK ^{[1
]}

LIANG, XZ ^{[1
]}

MIRHOM, YW ^{[1
]}

MITSCHER, LA ^{[1
]}

VANDERVELDE, DG ^{[1
]}

YE, QM ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT MED CHEM,LAWRENCE,KS 66045

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(00)80345-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

When taken at the appropriate time and place, biorenewable leaves of the abundant Himalayan yew, Taxus wallichiana Zucc., contain significant quantities (0.045-0.130%) of taxol and other useful taxanes including 10-deacetylbaccatin III and brevifoliol. Spectroscopic reexamination of brevifoliol indicates that its structure must be revised to 11. This makes brevifoliol and recently reported taxchinin A (12) close molecular relatives.

引用

页码：1345 / 1348

页数：4

共 23 条

[1] APPENDINO G, 1992, 2ND NAT CANC I WORKS
[2] DETERMINATION OF TAXOL BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY THERMOSPRAY MASS-SPECTROMETRY
AURIOLA, SOK
LEPISTO, AM
NAARANLAHTI, T
LAPINJOKI, SP
[J]. JOURNAL OF CHROMATOGRAPHY, 1992, 594 (1-2): : 153 - 158
[3] BREVIFOLIOL, A TAXANE FROM TAXUS-BREVIFOLIA
BALZA, F
TACHIBANA, S
BARRIOS, H
TOWERS, GHN
[J]. PHYTOCHEMISTRY, 1991, 30 (05) : 1613 - 1614
[4] BORMAN S, 1991, CHEM ENG NEWS 0902, P11
[5] CHAN WR, 1966, J CHEM SOC CHEM COMM, P923
[6] A HIGHLY EFFICIENT, PRACTICAL APPROACH TO NATURAL TAXOL
DENIS, JN
GREENE, AE
GUENARD, D
GUERITTEVOEGELEIN, F
MANGATAL, L
POTIER, P
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (17) : 5917 - 5919
[7] TAXCHININ-A - A DITERPENOID FROM TAXUS-CHINENSIS
FUJI, K
TANAKA, K
LI, B
SHINGU, T
SUN, HD
TAGA, T
[J]. TETRAHEDRON LETTERS, 1992, 33 (51) : 7915 - 7916
[8] SYNTHESIS OF BIOLOGICALLY-ACTIVE TAXOL ANALOGS WITH MODIFIED PHENYLISOSERINE SIDE-CHAINS
GEORG, GI
CHERUVALLATH, ZS
HIMES, RH
MEJILLANO, MR
BURKE, CT
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (22) : 4230 - 4237
[9] SEMISYNTHESIS AND BIOLOGICAL EVALUATION OF BREVIFOLIOL 13-[N-BENZOYL-(2'R,3'S)-3'-PHENYLISOSERINATE]
GEORG, GI
CHERUVALLATH, ZS
VANDERVELDE, D
YE, QM
MITSCHER, LA
HIMES, RH
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (06) : 1349 - 1350
[10] STRUCTURE OF A SYNTHETIC TAXOL PRECURSOR - N-TERT-BUTOXYCARBONYL-10-DEACETYL-N-DEBENZOYLTAXOL
GUERITTEVOEGELEIN, F
GUENARD, D
MANGATAL, L
POTIER, P
GUILHEM, J
CESARIO, M
PASCARD, C
[J]. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1990, 46 : 781 - 784

← 1 2 3 →