OXYGEN-TRANSPORT AND SOLUTION PROPERTIES OF POLYLIPID HB VESICLES (ARC)

被引：5

作者：

TAKEOKA, S ^{[1
]}

HASEGAWA, E ^{[1
]}

NISHIDE, H ^{[1
]}

TSUCHIDA, E ^{[1
]}

SEKIGUCHI, S ^{[1
]}

机构：

[1] HOKKAIDO RED CROSS BLOOD CTR,SAPPORO 063,JAPAN

来源：

BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY | 1992年 / 20卷 / 2-4期

关键词：

D O I：

10.3109/10731199209119659

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Polymerized phospholipid vesicle encapsulating Hb (polylipid/Hb vesicle) was prepared from a mixture of unsaturated phospholipid, cholesterol and unsaturated fatty acid and polymerization by gamma-ray irradiation. The average radius of resulting vesicles was 203 +/- 39 nm and concentrated Hb (30 wt%) was efficiently encapsulated. gamma-Ray polymerization proceeds theoretically at low temperature (4-degrees-C). P50 and oxygen transporting efficiency were adjusted to 40 mmHg and 40%, respectively. Oncotic pressure and solution viscosity can be controlled to the same values as blood.

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页码：399 / 404

页数：6

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