A STRAIGHTFORWARD APPROACH TO THE SYNTHESIS OF THE TRICYCLIC CORE OF TAXOL

被引：25

作者：

WANG, ZY ^{[1
]}

WARDER, SE ^{[1
]}

PERRIER, H ^{[1
]}

GRIMM, EL ^{[1
]}

BERNSTEIN, MA ^{[1
]}

BALL, RG ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD, RAHWAY, NJ 07065 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 11期

关键词：

D O I：

10.1021/jo00063a003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The tricyclic skeleton of taxol has been synthesized. The most challenging eight-membered ring was constructed through an intramolecular nucleophilic allylic bromide-aldehyde addition reaction promoted by Zn-Cu couple. © 1993, American Chemical Society. All rights reserved.

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页码：2931 / 2932

页数：2

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