STUDIES ON THE BIOSYNTHESIS OF DISCORHABDIN-B IN THE NEW-ZEALAND SPONGE LATRUNCULIA SP B

被引：39

作者：

LILL, RE

MAJOR, DA

BLUNT, JW

MUNRO, MHG

BATTERSHILL, CN

MCLEAN, MG

BAXTER, RL

机构：

[1] UNIV CANTERBURY,DEPT CHEM,CHRISTCHURCH 1,NEW ZEALAND

[2] DSIR,NEW ZEALAND OCEANOG INST,WELLINGTON,NEW ZEALAND

[3] UNIV EDINBURGH,DEPT CHEM,EDINBURGH EH9 3JJ,MIDLOTHIAN,SCOTLAND

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 02期

关键词：

D O I：

10.1021/np50116a028

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The production of discorhabdins in vivo by preparations of the marine sponge Latrunculia sp. B has been investigated. Slices of sponge tissue in an artificial medium were shown to effect the incorporation of radioactivity from [U-C-14]-L-phenylalanine into discorhabdin B [2], the principal cytotoxic metabolite produced by this organism. Additional experiments have shown that synthesis of this discorhabdin does nor require metabolic cooperation of symbiotic microorganisms.

引用

页码：306 / 311

页数：6

共 23 条

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