BETA-ADRENERGIC AGONIST-INDUCED LONG-LASTING SYNAPTIC MODIFICATIONS IN HIPPOCAMPAL DENTATE GYRUS REQUIRE ACTIVATION OF NMDA RECEPTORS, BUT NOT ELECTRICAL ACTIVATION OF AFFERENTS

被引：49

作者：

DAHL, D ^{[1
]}

SARVEY, JM ^{[1
]}

机构：

[1] UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,4301 JONES BRIDGE RD,BETHESDA,MD 20814

来源：

BRAIN RESEARCH | 1990年 / 526卷 / 02期

关键词：

Excitatory amino acids; Hippocampal formation; Long-term potentiation; Neuronal plasticity; NMDA receptor antagonists; Perforant pathway; Synaptic transmission; β-Adrenergic modulation;

D O I：

10.1016/0006-8993(90)91245-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Isoproterenol induced long-lasting potentiation (LLP) of the medial perforant path-evoked excitatory post-synaptic potential (EPSP) and long-lasting depression (LLD) of the lateral perforant path-evoked EPSP in the absence of perforant path activation. The NMDA receptor antagonist d-(-)-2-amino-5-phosphonovaleric acid [d(-)APV] blocked the induction of LLP and LLD. After wash, a subsequent exposure to isoproterenol induced only LLP of medial perforant path EPSPs; LLD of lateral perforant path-evoked EPSPs did not occur. Our results are consistent with the hypothesis that β-adrenergic agonist-induced synaptic modifications in the dentate gyrus arise from pre- and postsynaptic events. © 1990.

引用

页码：347 / 350

页数：4

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