ESTROGEN INCREASES AXODENDRITIC SYNAPSES IN THE VMN OF RATS AFTER OVARIECTOMY

被引：51

作者：

FRANKFURT, M

MCEWEN, BS

机构：

[1] Neuroendocrinology Laboratory, The Rockefeller University, New York, NY, 10021

来源：

NEUROREPORT | 1991年 / 2卷 / 07期

关键词：

ESTROGEN; VENTROMEDIAL HYPOTHALAMUS; SYNAPSE; AXON; DENDRITE; NEURAL PLASTICITY;

D O I：

10.1097/00001756-199107000-00006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Low doses of estrogen (E) were given to ovariectomized (OVX) rats and the ventromedial hypothalamic nucleus (VMN) was examined at the ultrastructural level. Administration of 10-mu-g of E for two consecutive days resulted in an increase in the number of axodendritic synapses in the VMN in comparison to OVX rats treated with oil. The percentage of axospine and multiple synapses and the length of the postsynaptic density were unchanged by E treatment. These results provide further support for the ability of low doses of E to alter neuronal morphology.

引用

页码：380 / 382

页数：3

共 13 条

[11] INTRINSIC SYNAPSES IN THE VENTROMEDIAL NUCLEUS OF THE HYPOTHALAMUS - AN ULTRASTRUCTURAL-STUDY [J].