HETEROGENEOUS PROLIFERATIVE EFFECT OF TUMOR-NECROSIS-FACTOR-ALPHA AND LYMPHOTOXIN ON MITOGEN-ACTIVATED B-CELLS FROM B-CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：7

作者：

ALVAREZMON, M

GARCIASUAREZ, J

PRIETO, A

MANZANO, L

REYES, E

LORENCES, C

PERAILE, G

JORDA, J

DURANTEZ, A

机构：

[1] UNIV AUTONOMA MADRID, CLIN PUERTA HIERRO, DEPT MED, SERV MED INTERNA, MADRID 34, SPAIN

[2] HOSP PRINCIPE ASTURIAS, SERV HEMATOL & MED INTERNA, MADRID, SPAIN

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1993年 / 43卷 / 02期

关键词：

INTERLEUKIN-2; B-CLL; INVITRO ACTIVATION OF B-CLL LYMPHOCYTES;

D O I：

10.1002/ajh.2830430202

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The proliferative effect of tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin on B cells from patients with B-chronic lymphocytic leukemia (B-CLL) was studied. Fresh purified B-CLL lymphocytes showed no proliferative response to either recombinant (r) TNF-alpha or r-lymphotoxin. However, after ''in vitro'' activation of B-CLL lymphocytes for 2 days with Staphylococcus aureus Cowan 1 (SAC), four of seven patients showed enhanced blastogenic response in the presence of either rTNF-alpha or r-lymphotoxin. We also found that the proliferative response of SAC-activated B-CLL lymphocytes to the two cytokines was independent of that found in the presence of interleukin-2. These results demonstrate that TNF-alpha and lymphotoxin can heterogeneously support the proliferation of in vitro activated B cells from B-CLL patients and may reflect the biological heterogeneity of B-CLL disease.

引用

页码：81 / 85

页数：5

共 25 条

[11]

GEISLER CH, 1991, BLOOD, V78, P1795

[12]

KARRAY S, 1987, BLOOD, V70, P1105

[13] EFFECT OF TUMOR-NECROSIS-FACTOR-ALPHA ON MITOGEN-ACTIVATED HUMAN B-CELLS [J].