A COMPARATIVE-STUDY OF MANGANESE MESO-SULFONATOPHENYL PORPHYRINS - CONTRAST-ENHANCING AGENTS FOR TUMORS

被引：50

作者：

FIEL, RJ

MUSSER, DA

MARK, EH

MAZURCHUK, R

ALLETTO, JJ

机构：

[1] Department of Biophysics, Roswell Park Memorial Institute, Buffalo

[2] Department of Pathophysiology, Roswell Park Memorial Institute, Buffalo

来源：

MAGNETIC RESONANCE IMAGING | 1990年 / 8卷 / 03期

关键词：

Contrast agents; MRI; Porphyrius;

D O I：

10.1016/0730-725X(90)90097-L

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Four manganese meso-sulfonatophenyl porphyrins were prepared, characterized and investigated for their potential as tumor-specific MRI contrast-enhancing agents in mice bearing subcutaneous implants of a mammary carcinoma (SMT-F). The trisulfonated tetraphenyl porphyrin, MnTPPS3 presented the most favorable profile: biodistribution, tumor concentration and tumor relaxivity, when compared at 24 hr postinjection. Imaging experiments revealed that a time-dependent delineation of tumor morphology occurs in response to MnTPPS3 that appears to correlate with necrotic regions of the tumor. © 1990.

引用

页码：255 / 259

页数：5

共 14 条

[1]

Chen, Cohen, Myers, Et al., Paramagnetic metalloporphyrins as potential contrast agents in NMR imaging, FEBS Lett., 168, pp. 70-74, (1984)

[2]

Patronas, Cohen, Knop, Et al., Metalloporphyrin contrast agents for magnetic resonance imaging of human tumors in mice, Cancer Treat. Rep., 70, pp. 391-395, (1986)

[3]

Fiel, Button, Gilani, Et al., Proton relaxation enhancement by manganese(III)TPPS<sub>4</sub> in a model tumor system, Magn. Reson. Imaging, 5, pp. 149-156, (1987)

[4]

Ogan, Didier, Brasch, Metalloporphyrin contrast enhancement of tumors in magnetic resonance imaging. A study of human carcinoma, lymphoma and fibrosarcoma in mice, Invest. Radiol., 22, pp. 822-828, (1987)

[5]

Furmanski, Longley, Metalloporphyrin enhancement of magnetic resonance imaging of human tumor xenografts in nude mice, Cancer Res., 48, pp. 4604-4610, (1988)

[6]

Megnin, Faustino, Lyon, Et al., Studies on the mechanism of selective retention of porphyrins and metalloporphyrins by cancer cells, Biochim. Biophys. Acta, 929, pp. 173-181, (1987)

[7]

Fiel, Mark, Button, Et al., Mechanism of the localization of manganese(III)meso-tetra(4-sulfonatophenyl)porphine in mice bearing L1210 tumors, Cancer Lett., 40, pp. 23-32, (1988)

[8]

Fiel, Porphyrin-nucleic acid interactions A review, Journal of Biomolecular Structure and Dynamics, 6, pp. 1-16, (1989)

[9]

Henkelman, van Heteran, Bronskill, Small animal imaging with a clinical imager, Magn. Reson. Med., 4, pp. 61-66, (1987)

[10]

Zahl, Waters, Localization of colloidal dyes in animal tumors, Experimental Biology and Medicine, 48, pp. 304-307, (1941)

← 1 2 →