A COMPARATIVE-STUDY OF MANGANESE MESO-SULFONATOPHENYL PORPHYRINS - CONTRAST-ENHANCING AGENTS FOR TUMORS

被引：50

作者：

FIEL, RJ

MUSSER, DA

MARK, EH

MAZURCHUK, R

ALLETTO, JJ

机构：

[1] Department of Biophysics, Roswell Park Memorial Institute, Buffalo

[2] Department of Pathophysiology, Roswell Park Memorial Institute, Buffalo

来源：

MAGNETIC RESONANCE IMAGING | 1990年 / 8卷 / 03期

关键词：

Contrast agents; MRI; Porphyrius;

D O I：

10.1016/0730-725X(90)90097-L

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Four manganese meso-sulfonatophenyl porphyrins were prepared, characterized and investigated for their potential as tumor-specific MRI contrast-enhancing agents in mice bearing subcutaneous implants of a mammary carcinoma (SMT-F). The trisulfonated tetraphenyl porphyrin, MnTPPS3 presented the most favorable profile: biodistribution, tumor concentration and tumor relaxivity, when compared at 24 hr postinjection. Imaging experiments revealed that a time-dependent delineation of tumor morphology occurs in response to MnTPPS3 that appears to correlate with necrotic regions of the tumor. © 1990.

引用

页码：255 / 259

页数：5

共 14 条

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