EFFECT OF SCOPOLAMINE AND NOOTROPIC DRUGS ON REWARDED ALTERNATION IN A T-MAZE

被引：29

作者：

BARTOLINI, L ^{[1
]}

RISALITI, R ^{[1
]}

PEPEU, G ^{[1
]}

机构：

[1] UNIV FLORENCE,DEPT PRECLIN & CLIN PHARMACOL,VIALE MORGAGNI 65,I-50134 FLORENCE,ITALY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 43卷 / 04期

关键词：

NOOTROPIC DRUGS; OXIRACETAM; ANIRACETAM; SCOPOLAMINE; T-MAZE; ALTERNATION;

D O I：

10.1016/0091-3057(92)90497-4

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of different doses of scopolamine, and of the nootropic drugs oxiracetam and aniracetam, were investigated on the performance of male Wistar rats in a T-maze requiring a spatial discrimination in the stem (reference memory) and an alternate discrimination in the arms (working memory). Criterion (90% correct responses) was reached within 3 days of daily training for stem and 9 days for arm discrimination. Scopolamine (0.1, 0.2, 0.6, and 1.0 mg/kg, SC, 60 min before session) significantly impaired working memory, as shown by a decrease in the number of correct alternations, without affecting reference memory. Both nootropic drugs (25-50 and 100 mg/kg PO) 30 min before scopolamine) attenuated the working memory impairment induced by scopolamine.

引用

页码：1161 / 1164

页数：4

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