MYOGENIN BINDS TO AND REPRESSES C-FOS PROMOTER

被引：14

作者：

TROUCHE, D

MASUTANI, H

GROISMAN, R

ROBIN, P

LENORMAND, JL

HARELBELLAN, A

机构：

[1] INST GUSTAVE ROUSSY,BIOL TUMEURS HUMAINES LAB,CNRS,URA 1156,F-94805 VILLEJUIF,FRANCE

[2] INST GUSTAVE ROUSSY,ONCOL MOLEC LAB,CNRS,URA 1967,F-94805 VILLEJUIF,FRANCE

来源：

FEBS LETTERS | 1995年 / 361卷 / 2-3期

关键词：

MYOGENIN; C-FOS; SERUM RESPONSE ELEMENT;

D O I：

10.1016/0014-5793(95)00140-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Myogenin (a member of the myogenic basic helix-loop-helix transcription factor family) seems to be the main effector of proliferation repression, a crucial step which precedes muscle cell terminal differentiation during muscle development. Proliferation repression most likely occurs through inhibition of proliferation-associated genes such as the proto-oncogene, c-fos. Here, we demonstrate that myogenin binds to an E-box located in the main element of the c-fos promoter, the serum response element (SRE). Results from co-transfection experiments indicate that myogenin acts as a repressor for the SRE. Our data suggest that myogenin could play a role in c-fos inhibition at the onset of muscle cell terminal differentiation.

引用

页码：140 / 144

页数：5

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