EFFECTS OF DANAZOL AT THE IMMUNOLOGICAL LEVEL IN PATIENTS WITH ADENOMYOSIS, WITH SPECIAL REFERENCE TO AUTOANTIBODIES - A MULTICENTER COOPERATIVE STUDY

被引：35

作者：

OTA, H

MAKI, M

SHIDARA, Y

KODAMA, H

TAKAHASHI, H

HAYAKAWA, M

FUJIMORI, R

KUSHIMA, T

OHTOMO, K

机构：

[1] AKITA UNIV,SCH MED,AKITA 010,JAPAN

[2] YAMAMOTO KUMIAI GEN HOSP,DEPT OBSTET & GYNECOL,NOSHIRO,JAPAN

[3] KOTO GEN HOSP,DEPT OBSTET & GYNECOL,HACHIROGATA,JAPAN

[4] AKITA RED CROSS HOSP,DEPT OBSTET & GYNECOL,AKITA,JAPAN

[5] SENBOKU KUMIAI GEN HOSP,DEPT OBSTET & GYNECOL,OMAGARI,JAPAN

[6] YOKOTE MUNICIPAL HOSP,DEPT OBSTET & GYNECOL,YOKOTE,JAPAN

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1992年 / 167卷 / 02期

关键词：

ADENOMYOSIS; ENDOMETRIOSIS; AUTOANTIBODY; AUTOIMMUNITY; DANAZOL;

D O I：

10.1016/S0002-9378(11)91433-1

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: We attempted to evaluate the effects of danazol on autoantibodies, in particular, to phospholipids, and on the immune system in patients with adenomyosis. STUDY DESIGN: Forty-two patients with adenomyosis who had high titers of autoantibodies were randomly chosen, and they received 400 mg/day of danazol for 4 months (n = 22) or underwent hysterectomy (n = 20). RESULTS: Among the six autoantibodies we investigated, the incidence of antiphosphatidylinositol immunoglobulin G was the highest (42.9%), followed by antiphosphatidylglycerol immunoglobulin G (38.1%). The autoantibody titers decreased with time and were comparable to the control values 16 weeks after treatment in both groups. Total serum levels of immunoglobulin G and M were high before treatment, but immunoglobulin M levels decreased significantly in week 8 during treatment with danazol, whereas C4 levels increased and C3 levels decreased with danazol. CONCLUSION: Danazol has an inhibitory effect on the autoimmunologic response associated with adenomyosis.

引用

页码：481 / 486

页数：6