DIFFERENT RATES OF NEURONAL DEGENERATION - AN EXQUISITE VARIATION OF THE CASCADE HYPOTHESIS

被引:4
作者
DANI, SU
PITTELLA, JEH
HORI, A
BERGMANN, B
STAN, AC
WALTER, GF
机构
[1] FED UNIV RIO DE JANEIRO,INST BIOFIS CARLOS CHAGAS FILHO,DEPT NEUROBIOL,RIO JANEIRO,BRAZIL
[2] UNIV FED MINAS GERAIS,FAC MED,DEPT PATHOL & LEGAL MED,BELO HORIZONT,MG,BRAZIL
来源
DEMENTIA | 1994年 / 5卷 / 02期
关键词
AGING; HIPPOCAMPUS; NEURITIC PLAQUES; NEUROFIBRILLARY TANGLES; ALZHEIMERS DISEASE; GEOGRAPHICAL DIFFERENCES;
D O I
10.1159/000106705
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
This morphometric, quantitative and correlative multivariate study of the hippocampal formation in human brains from two distinct normal aging populations provides an additional support to the notion that neuritic plaques (NP) are an earlier stage of the pathological process underlying neurofibrillary tangle (NFT) formation. It is shown that the rate of transformation of NP-affected neurons into NFT-bearing neurons may vary remarkably between distinct populations. In addition, it is put forward that different rates of neuronal degeneration may be one of the explanations for the existence of conflicting hypotheses regarding pathogenesis of NP and NFT and the relationships of these important histological markers to psychical deterioration.
引用
收藏
页码:110 / 118
页数:9
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