INDIVIDUAL HOUSING MODULATES DAILY RHYTHMS OF HYPOTHALAMIC CATECHOLAMINERGIC SYSTEM AND CIRCULATING HORMONES IN ADULT MALE-RATS

被引：36

作者：

GAMBARDELLA, P ^{[1
]}

GRECO, AM ^{[1
]}

STICCHI, R ^{[1
]}

BELLOTTI, R ^{[1
]}

DIRENZO, G ^{[1
]}

机构：

[1] UNIV NAPOLI FEDERICO II,FAC MED & CHIRURG,IST FARMACOL SPERIMENTALE & CLIN,I-80131 NAPLES,ITALY

来源：

CHRONOBIOLOGY INTERNATIONAL | 1994年 / 11卷 / 04期

关键词：

INDIVIDUAL HOUSING; MALE ADULT RATS; CIRCADIAN RHYTHMS; HYPOTHALAMIC CATECHOLAMINES AND METABOLITES; CIRCULATING PROLACTIN AND CORTICOSTERONE;

D O I：

10.3109/07420529409067790

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Circadian rhythms of hypothalamic catecholamines and their metabolites and of prolactin and corticosterone circulating hormones were determined over 24 h in group-housed (six per cage; control) and individually housed, 90-day-old male albino rats adapted to a 12:12 light/dark cycle. After 5 weeks of adaptation, in individually housed rats, norepinephrine (NE) turnover increased, since lower NE (p < 0.01) and higher MOPEG metabolite (p < 0.01) levels were measured. As concerns the dopaminergic system, individually housed rats increased both dopamine (DA) synthesis and turnover as revealed by higher DOPAC (p < 0.01) and HVA (p < 0.05) metabolites without modification of DA levels. Moreover, in individually housed rats, corticosterone (p < 0.01) and prolactin (p < 0.05) mean levels were higher than in the control group.

引用

页码：213 / 221

页数：9