RENAL EFFECTS OF GROWTH-HORMONE .2. ELECTROLYTE HOMEOSTASIS AND BODY-COMPOSITION

被引：32

作者：

OGLE, GD ^{[1
]}

ROSENBERG, AR ^{[1
]}

KAINER, G ^{[1
]}

机构：

[1] PRINCE WALES CHILDRENS HOSP,DEPT NEPHROL,HIGH ST,SYDNEY,NSW 2031,AUSTRALIA

来源：

PEDIATRIC NEPHROLOGY | 1992年 / 6卷 / 05期

关键词：

GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR-I; CALCIUM HOMEOSTASIS; BODY COMPOSITION;

D O I：

10.1007/BF00874021

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Growth hormone (GH), either directly or through insulin-like growth factor-1 (IGF-1), has a wide spectrum of physiological and renal effects. This review concentrates on the effects of GH (derived from either pituitary or recombinant technology) and IGF-1 in three main areas: (1) sodium and water homeostasis; (2) calcium and phosphate balance, bone density and interactions with mineral regulating hormones; (3) fat and lean body mass. Observations of physiological changes in states of GH deficiency and excess in humans and animal models are presented. The lack of long-term toxicological data indicates that GH treatment for short stature in non-GH deficient children, with or without renal disease, should proceed with caution.

引用

页码：483 / 489

页数：7

共 85 条

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