THE TASP CONCEPT - MIMETICS OF PEPTIDE LIGANDS, PROTEIN SURFACES AND FOLDING UNITS

被引：47

作者：

TUCHSCHERER, G ^{[1
]}

DOMER, B ^{[1
]}

SILA, U ^{[1
]}

KAMBER, B ^{[1
]}

MUTTER, M ^{[1
]}

机构：

[1] CIBA GEIGY AG, CH-4002 BASEL, SWITZERLAND

来源：

TETRAHEDRON | 1993年 / 49卷 / 17期

关键词：

D O I：

10.1016/S0040-4020(01)90215-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The TASP (Template Assembled Synthetic Protein) concept in protein de novo design has been introduced for the construction of protein-like molecules exhibiting tailor made functional properties. After establishing some synthetic and conformational foundations in TASP strategy, we describe a 4alpha - helix bundle TASP molecule mimicking immunological properties of human MHC-I. Furthermore, we focus on structural motifs (eg. topological templates) disposing functional groups in defined spatial positions as candidates to mimic structural and conformational features of peptides and proteins for molecular recognition studies.

引用

页码：3559 / 3575

页数：17

共 44 条

[1]

BARANY G, 1980, PEPTIDES, P1

[2]

BIANCO A, 1992, UNPUB PEPTIDES

[3] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].