OPTIMIZATION OF ANTISENSE CHIMERIC OLIGONUCLEOTIDES CONTAINING ALPHA-ANOMERIC AND BETA-ANOMERIC DEOXYNUCLEOTIDES

被引：4

作者：

DEBART, F

TOSQUELLAS, G

RAYNER, B

IMBACH, JL

机构：

[1] Laboratoire de Chimie Bio-organique, URA 488 CNRS, Case 008, Université Montpellier II, 34095, Montpellier, Cedex 5, Place Eugène Bataillon

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012523

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Various chimeric oligonucleotides containing alpha- and beta-anomeric deoxynucleotide units and directed against the splice acceptor site of the HIV-1 tat RNA have been synthesized. Their hybridizing abilities to complementary DNA or RNA single strands, and their stability in cell culture medium or cell extracts were studied.

引用

页码：1015 / 1018

页数：4

共 6 条

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[5] ONLINE INTERNAL SURFACE REVERSED-PHASE CLEANING - THE DIRECT HPLC ANALYSIS OF CRUDE BIOLOGICAL SAMPLES - APPLICATION TO THE KINETICS OF DEGRADATION OF OLIGONUCLEOTIDES IN CELL-CULTURE MEDIUM
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IMBACH, JL
[J]. BIOCHEMICAL PHARMACOLOGY, 1992, 43 (08) : 1769 - 1775
[6] NEW INSIGHTS INTO THE RESISTANCE OF ALPHA-OLIGONUCLEOTIDES TO NUCLEASES
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IMBACH, JL
[J]. ANTISENSE RESEARCH AND DEVELOPMENT, 1994, 4 (01): : 9 - 18

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