ANALOGS OF THE ANTIVIRAL ACYCLONUCLEOSIDE 9-(4-HYDROXY-3-HYDROXYMETHYLBUTYL)GUANINE .4. SUBSTITUTION ON THE 2-AMINO GROUP

被引：12

作者：

HARNDEN, MR ^{[1
]}

JARVEST, RL ^{[1
]}

机构：

[1] BEECHAM PHARMACEUT, DIV RES, YEW TREE BOTTOM RD, EPSOM KT18 5XQ, SURREY, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1989年 / 12期

关键词：

D O I：

10.1039/p19890002207

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

引用

页码：2207 / 2213

页数：7

共 28 条

[1] ANALOGS OF THE ANTIVIRAL ACYCLONUCLEOSIDE 9-(4-HYDROXY-3-HYDROXY-METHYLBUTYL)GUANINE .2. SUBSTITUTIONS ON C-1' AND C-3' OF THE ACYCLIC N-9 SUBSTITUENT [J].

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[3] ANTIHERPESVIRUS ACTIVITY OF 9-(4-HYDROXY-3-HYDROXYMETHYLBUT-1-YL)GUANINE (BRL-39123) IN CELL-CULTURE [J].

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[5] THE SYNTHESES OF ACYCLOFORMYCINS AND 5-AMINO-3-(2-HYDROXYETHOXY)-METHYLPYRAZOLO[4,3-D]PYRIMIDIN-7(6H)-ONE, AN ANALOG OF THE ANTIVIRAL ACYCLOGUANOSINE [J].

ELLAMES, GJ ;

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JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (10) :2087-2091

[6] ANALOGS OF THE ANTIVIRAL ACYCLONUCLEOSIDE 9-(4-HYDROXY-3-HYDROXY-METHYLBUTYL)GUANINE .3. MODIFICATION OF A 3'-HYDROXYMETHYL GROUP [J].

HARNDEN, MR ;

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JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1988, (10) :2777-2784

[7] SYNTHESIS OF 9-(HYDROXYALKYLAMINO)GUANINES, NOVEL ANTIVIRAL ACYCLONUCLEOSIDES [J].

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[8] ANALOGS OF THE ANTIVIRAL ACYCLONUCLEOSIDE 9-(4-HYDROXY-3-HYDROXYMETHYLBUTYL)GUANINE .1. SUBSTITUTIONS ON C-2' OF THE ACYCLIC N-9 SUBSTITUENT [J].

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JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1988, (10) :2757-2765

[9] AN IMPROVED SYNTHESIS OF THE ANTIVIRAL ACYCLONUCLEOSIDE 9-(4-HYDROXY-3-HYDROXYMETHYLBUT-1-YL)GUANINE [J].

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[10] PRODRUGS OF THE SELECTIVE ANTIHERPESVIRUS AGENT 9-[4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL]GUANINE (BRL 39123) WITH IMPROVED GASTROINTESTINAL ABSORPTION PROPERTIES [J].

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JARVEST, RL ;

BOYD, MR ;

SUTTON, D ;

HODGE, RAV .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (08) :1738-1743

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