THE ROLE OF RECEPTOR SUBTYPE DIVERSITY IN THE CNS

被引:86
作者
SCHOFIELD, PR [1 ]
SHIVERS, BD [1 ]
SEEBURG, PH [1 ]
机构
[1] UNIV HEIDELBERG,CTR MOLEC BIOL,W-6900 HEIDELBERG,GERMANY
关键词
D O I
10.1016/0166-2236(90)90052-C
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The molecular characterization of neuroreceptors and voltage-gated ion channels has revealed that receptor subtype heterogeneity is a common feature of chemical and electrical signal reception. The use of distinct genes encoding receptor subtypes is a favoured mechanism for generation of this diversity. We propose that the significance of the multiplicity and diversity of signal reception proteins is to increase the information-handling capacity of neurons. This may contribute to neural plasticity. © 1990.
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页码:8 / 11
页数:4
相关论文
共 58 条
  • [1] A STUDY OF THE ADRENOTROPIC RECEPTORS
    AHLQUIST, RP
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1948, 153 (03): : 586 - 600
  • [2] ALTERNATIVE RNA PROCESSING IN CALCITONIN GENE-EXPRESSION GENERATES MESSENGER-RNAS ENCODING DIFFERENT POLYPEPTIDE PRODUCTS
    AMARA, SG
    JONAS, V
    ROSENFELD, MG
    ONG, ES
    EVANS, RM
    [J]. NATURE, 1982, 298 (5871) : 240 - 244
  • [3] AN M2 MUSCARINIC RECEPTOR SUBTYPE COUPLED TO BOTH ADENYLYL CYCLASE AND PHOSPHOINOSITIDE TURNOVER
    ASHKENAZI, A
    WINSLOW, JW
    PERALTA, EG
    PETERSON, GL
    SCHIMERLIK, MI
    CAPON, DJ
    RAMACHANDRAN, J
    [J]. SCIENCE, 1987, 238 (4827) : 672 - 675
  • [4] REGULATING THE NUMBER AND FUNCTION OF NEURONAL ACETYLCHOLINE-RECEPTORS
    BERG, DK
    BOYD, RT
    HALVORSEN, SW
    HIGGINS, LS
    JACOB, MH
    MARGIOTTA, JF
    [J]. TRENDS IN NEUROSCIENCES, 1989, 12 (01) : 16 - 21
  • [5] IDENTIFICATION OF A FAMILY OF MUSCARINIC ACETYLCHOLINE-RECEPTOR GENES
    BONNER, TI
    BUCKLEY, NJ
    YOUNG, AC
    BRANN, MR
    [J]. SCIENCE, 1987, 237 (4814) : 527 - 532
  • [6] CLONING AND EXPRESSION OF THE HUMAN AND RAT M5 MUSCARINIC ACETYLCHOLINE-RECEPTOR GENES
    BONNER, TI
    YOUNG, AC
    BRANN, MR
    BUCKLEY, NJ
    [J]. NEURON, 1988, 1 (05) : 403 - 410
  • [7] ISOLATION OF A CDNA CLONE CODING FOR A POSSIBLE NEURAL NICOTINIC ACETYLCHOLINE-RECEPTOR ALPHA-SUBUNIT
    BOULTER, J
    EVANS, K
    GOLDMAN, D
    MARTIN, G
    TRECO, D
    HEINEMANN, S
    PATRICK, J
    [J]. NATURE, 1986, 319 (6052) : 368 - 374
  • [8] BUCKLEY NJ, 1988, J NEUROSCI, V8, P4646
  • [9] CONTROL OF TORPEDO ACETYLCHOLINE-RECEPTOR BIOSYNTHESIS IN XENOPUS OOCYTES
    BULLER, AL
    WHITE, MM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (22) : 8717 - 8721
  • [10] A FAMILY OF PUTATIVE POTASSIUM CHANNEL GENES IN DROSOPHILA
    BUTLER, A
    WEI, A
    BAKER, K
    SALKOFF, L
    [J]. SCIENCE, 1989, 243 (4893) : 943 - 947