INHIBITORY EFFECTS OF TRIPTOGELIN-A-1 ON 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED SKIN TUMOR PROMOTION

被引：39

作者：

UJITA, K

TAKAISHI, Y

TOKUDA, H

NISHINO, H

IWASHIMA, A

FUJITA, T

机构：

[1] UNIV TOKUSHIMA,FAC PHARMACEUT SCI,SHOMACHI 1-78,TOKUSHIMA 770,JAPAN

[2] KYOTO UNIV,FAC PHARMACEUT SCI,KYOTO 606,JAPAN

[3] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KYOTO 602,JAPAN

来源：

CANCER LETTERS | 1993年 / 68卷 / 2-3期

关键词：

DIHYDROAGAROFURAN SESQUITERPENE; EPSTEIN-BARR VIRUS ACTIVATION; ANTITUMOR PROMOTION; 12-O-TETRADECANOYLPHORBOL-13-ACETATE;

D O I：

10.1016/0304-3835(93)90138-Y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA)-activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Triptogelin A-1, one of the active dihydroagarofuran sesquiterpenes, exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Interestingly, triptogelin A-1 was more effective when applied after TPA-treatment (post-treatment) than before TPA-treatment (pretreatment). The findings indicate that these dihydroagarofuran sesquiterpenes might be valuable antitumor promoters.

引用

收藏

页码：129 / 133

页数：5

相关论文

共 28 条

[1] THE EPSTEIN-BARR VIRUS EARLY ANTIGEN INDUCING INDOLE ALKALOIDS, (-)-INDOLACTAM-V AND ITS RELATED-COMPOUNDS, PRODUCED BY ACTINOMYCETES [J].

IRIE, K ;

HIROTA, M ;

HAGIWARA, N ;

KOSHIMIZU, K ;

HAYASHI, H ;

MURAO, S ;

TOKUDA, H ;

ITO, Y .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1984, 48 (05) :1269-1274

[2] EPSTEIN-BARR VIRUS-ACTIVATION BY TUNG OIL, EXTRACTS OF ALEURITES-FORDII AND ITS DITERPENE ESTER 12-O-HEXADECANOYL-16-HYDROXYPHORBOL-13-ACETATE [J].

ITO, Y ;

YANASE, S ;

TOKUDA, H ;

KISHISHITA, M ;

OHIGASHI, H ;

HIROTA, M ;

KOSHIMIZU, K .

CANCER LETTERS, 1983, 18 (01) :87-95

[3] A SHORT-TERM INVITRO ASSAY FOR PROMOTER SUBSTANCES USING HUMAN-LYMPHOBLASTOID CELLS LATENTLY INFECTED WITH EPSTEIN-BARR VIRUS [J].

ITO, Y ;

YANASE, S ;

FUJITA, J ;

HARAYAMA, T ;

TAKASHIMA, M ;

IMANAKA, H .

CANCER LETTERS, 1981, 13 (01) :29-37

[4] COMBINED EFFECT OF THE EXTRACTS FROM CROTON-TIGLIUM, EUPHORBIA-LATHYRIS OR EUPHORBIA-TIRUCALLI AND NORMAL-BUTYRATE ON EPSTEIN-BARR VIRUS EXPRESSION IN HUMAN-LYMPHOBLASTOID P3HR-1 AND RAJI CELLS [J].

ITO, Y ;

KAWANISHI, M ;

HARAYAMA, T ;

TAKABAYASHI, S .

CANCER LETTERS, 1981, 12 (03) :175-180

[5] STUDIES ON INHIBITORS OF SKIN TUMOR PROMOTION .3. INHIBITORY EFFECTS OF ISOFLAVONOIDS FROM WISTERIA-BRACHYBOTRYS ON EPSTEIN-BARR VIRUS-ACTIVATION [J].

KONOSHIMA, T ;

OKAMOTO, E ;

KOZUKA, M ;

NISHINO, H ;

TOKUDA, H ;

TANABE, M .

JOURNAL OF NATURAL PRODUCTS, 1988, 51 (06) :1266-1270

[6] STUDIES ON INHIBITORS OF SKIN TUMOR PROMOTION .9. NEOLIGNANS FROM MAGNOLIA-OFFICINALIS [J].

KONOSHIMA, T ;

KOZUKA, M ;

TOKUDA, H ;

NISHINO, H ;

IWASHIMA, A ;

HARUNA, M ;

ITO, K ;

TANABE, M .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (03) :816-822

[7]

KONOSHIMA T, 1989, Shoyakugaku Zasshi, V43, P135

[8]

Matsumoto T, 1990, Basic Life Sci, V52, P423

[9] ANTITUMOR-PROMOTING ACTIVITY OF GLYCYRRHETIC ACID IN MOUSE SKIN TUMOR-FORMATION INDUCED BY 7,12-DIMETHYLBENZ[A]ANTHRACENE PLUS TELEOCIDIN [J].

NISHINO, H ;

KITAGAWA, K ;

IWASHIMA, A .

CARCINOGENESIS, 1984, 5 (11) :1529-1530

[10] SEARCH FOR POSSIBLE ANTITUMOR PROMOTERS BY INHIBITION OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED EPSTEIN-BARR VIRUS-ACTIVATION - URSOLIC ACID AND OLEANOLIC ACID FROM AN ANTIINFLAMMATORY CHINESE MEDICINAL PLANT, GLECHOMA-HEDERACEAE L [J].

OHIGASHI, H ;

TAKAMURA, H ;

KOSHIMIZU, K ;

TOKUDA, H ;

ITO, Y .

CANCER LETTERS, 1986, 30 (02) :143-151