INHIBITORY EFFECTS OF TRIPTOGELIN-A-1 ON 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED SKIN TUMOR PROMOTION

被引：39

作者：

UJITA, K

TAKAISHI, Y

TOKUDA, H

NISHINO, H

IWASHIMA, A

FUJITA, T

机构：

[1] UNIV TOKUSHIMA,FAC PHARMACEUT SCI,SHOMACHI 1-78,TOKUSHIMA 770,JAPAN

[2] KYOTO UNIV,FAC PHARMACEUT SCI,KYOTO 606,JAPAN

[3] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KYOTO 602,JAPAN

来源：

CANCER LETTERS | 1993年 / 68卷 / 2-3期

关键词：

DIHYDROAGAROFURAN SESQUITERPENE; EPSTEIN-BARR VIRUS ACTIVATION; ANTITUMOR PROMOTION; 12-O-TETRADECANOYLPHORBOL-13-ACETATE;

D O I：

10.1016/0304-3835(93)90138-Y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA)-activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Triptogelin A-1, one of the active dihydroagarofuran sesquiterpenes, exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Interestingly, triptogelin A-1 was more effective when applied after TPA-treatment (post-treatment) than before TPA-treatment (pretreatment). The findings indicate that these dihydroagarofuran sesquiterpenes might be valuable antitumor promoters.

引用

页码：129 / 133

页数：5

共 28 条

[11] TIGLIANE TYPE DITERPENE-ESTERS WITH EPSTEIN-BARR VIRUS-INDUCING ACTIVITY FROM SAPIUM-SEBIFERUM [J].