Metastasis Update: Human Prostate Carcinoma Invasion via Tubulogenesis

被引：24

作者：

Nagle, Raymond B. ^{[1
]}

Cress, Anne E. ^{[2
]}

机构：

[1] Univ Arizona, Arizona Canc Ctr, Dept Pathol, Tucson, AZ 85724 USA

[2] Univ Arizona, Dep Cellular & Mol Med, Tucson, AZ 85724 USA

来源：

PROSTATE CANCER | 2011年 / 2011卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1155/2011/249290

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

This paper proposes that human prostate carcinoma primarily invades as a cohesive cell collective through a mechanism similar to embryonic tubulogenesis, instead of the popular epithelial-mesenchymal transformation (EMT) model. Evidence supporting a tubulogenesis model is presented, along with suggestions for additional research. Additionally, observations documenting cell adhesion molecule changes in tissue and stromal components are reviewed, allowing for comparisons between the current branching morphogenesis models and the tubulogenesis model. Finally, the implications of this model on prevailing views of therapeutic and diagnostic strategies for aggressive prostatic disease are considered.

引用

页数：10

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