AUTOMATIC-DETERMINATION OF AMYLOCAINE AND BROMHEXINE BY ATOMIC-ABSORPTION SPECTROMETRY

被引：12

作者：

EISMAN, M ^{[1
]}

GALLEGO, M ^{[1
]}

VALCARCEL, M ^{[1
]}

机构：

[1] UNIV CORDOBA,FAC SCI,DEPT ANALYT CHEM,E-14004 CORDOBA,SPAIN

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 4-5期

关键词：

AMYLOCAINE; BROMHEXINE; CONTINUOUS LIQUID LIQUID EXTRACTION; ATOMIC ABSORPTION SPECTROMETRY;

D O I：

10.1016/0731-7085(93)80021-R

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An automatic method for the determination of amylocaine and bromhexine hydrochloride by atomic absorption spectrometry (AAS) is proposed. The drugs were determined indirectly by formation of reineckates, extraction into 1,2-dichloroethane and measurement of chromium in the organic phase. The chemical conditions and experimental variables influencing the performance of the flow system of the liquid-liquid extractor were established. The proposed method allows the determination of amylocaine and bromhexine at concentrations between 3 and 120 mug ml-1 with a relative standard deviation of 1 and 3%, respectively, even in the presence of other synthetic drugs.

引用

页码：301 / 305

页数：5

共 14 条

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[13] USE OF ABSORBANCE RATIOS IN DENSITOMETRIC MEASUREMENTS FOR THE CHARACTERIZATION AND IDENTIFICATION OF NATURAL-PRODUCTS OF PHARMACOLOGICAL INTEREST [J].

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[14]

1989, MARTINDALE EXTRA PHA

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