INHIBITION AND INACTIVATION OF ESTROGEN SYNTHETASE (AROMATASE) BY FLUORINATED SUBSTRATE-ANALOGS

被引：62

作者：

MARCOTTE, PA ^{[1
]}

ROBINSON, CH ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21205

来源：

BIOCHEMISTRY | 1982年 / 21卷 / 11期

关键词：

D O I：

10.1021/bi00540a030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：2773 / 2778

页数：6

共 20 条

[1] STEROIDS .230. CONVERSION OF 6-BETA,19-OXIDES AND LACTONES INTO 19-NOR STEROIDS [J].

BERKOZ, B ;

DENOT, E ;

BOWERS, A .

STEROIDS, 1963, 1 (03) :251-270

[2] INHIBITION OF TESTOSTERONE 5-ALPHA-REDUCTASE BY A PROPOSED ENZYME-ACTIVATED, ACTIVE SITE-DIRECTED INHIBITOR [J].

BLOHM, TR ;

METCALF, BW ;

LAUGHLIN, ME ;

SJOERDSMA, A ;

SCHATZMAN, GL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 95 (01) :273-280

[3] INACTIVATION OF AROMATASE INVITRO BY 4-HYDROXY-4-ANDROSTENE-3, 17-DIONE AND 4-ACETOXY-4-ANDROSTENE-3, 17-DIONE AND SUSTAINED EFFECTS INVIVO [J].

BRODIE, AMH ;

GARRETT, WM ;

HENDRICKSON, JR ;

TSAIMORRIS, CH ;

MARCOTTE, PA ;

ROBINSON, CH .

STEROIDS, 1981, 38 (06) :693-702

[4] AROMATASE INHIBITORS .4. REGRESSION OF HORMONE-DEPENDENT, MAMMARY-TUMORS IN THE RAT WITH 4-ACETOXY-4-ANDROSTENE-3,17-DIONE [J].

BRODIE, AMH ;

MARSH, D ;

BRODIE, HJ .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1979, 10 (04) :423-429

[5] EFFECT OF AN AROMATASE INHIBITOR, 4-HYDROXY-4-ANDROSTENE-3,17-DIONE, ON ESTROGEN-DEPENDENT PROCESSES IN REPRODUCTION AND BREAST-CANCER [J].

BRODIE, AMH ;

SCHWARZEL, WC ;

SHAIKH, AA ;

BRODIE, HJ .

ENDOCRINOLOGY, 1977, 100 (06) :1684-1695

[6]

COVEY DF, 1981, J BIOL CHEM, V256, P1076

[7] C-19 FUNCTIONAL STEROIDS .5. SYNTHESIS OF ESTROGEN BIOSYNTHESIS INTERMEDIATES [J].

JEN, T ;

WOLFF, ME .

JOURNAL OF ORGANIC CHEMISTRY, 1963, 28 (06) :1573-&

[8] 19-NORSTEROIDE .4. UBER DIE REDUKTIVE ATHERSPALTUNG BEI 5ALPHA-HALOGEN-6BETA,19-OXIDO-STEROIDEN [J].

KALVODA, J ;

HEUSLER, K ;

ANNER, G ;

WETTSTEIN, A ;

UEBERNWAS.H .

HELVETICA CHIMICA ACTA, 1963, 46 (04) :1361-&

[9]

KITZ R, 1962, J BIOL CHEM, V237, P3245

[10]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

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