EFFECTS OF SEIZURES ON LEARNING, MEMORY, AND BEHAVIOR IN THE GENETICALLY EPILEPSY-PRONE RAT

被引:57
作者
HOLMES, GL
THOMPSON, JL
MARCHI, TA
GABRIEL, PS
HOGAN, MA
CARL, FG
FELDMAN, DS
机构
[1] VET ADM MED CTR,AUGUSTA,GA 30904
[2] MED COLL GEORGIA,AUGUSTA,GA 30912
关键词
D O I
10.1002/ana.410270106
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
To determine whether frequent seizures can cause deficits in learning and behavior, immature genetically epilepsyprone rats (GEPRs) were subjected to 66 audiogenic stimulations (Group 1). GEPR littermates were handled and placed in the sound chamber but were not stimulated (Group 2). Group 3 comprised genetically epilepsy‐resistant rats (GERRs) who received audiogenic stimulations but had no seizures. After 3 weeks of stimulations the rats were tested for learning, memory, and behavior using the T‐maze, water maze, open field activity test, home cage intruder test, and handling test. When compared with the control GEPRs and GERRs, Group 1 rats reached criteria less frequently in the T‐maze, required longer times to find the platform in the water maze, and were active in the open field activity test, less aggressive in the home cage intruder test, and more irritable and aggressive in the handling test. This study demonstrates that frequent, brief seizures in immature animals result in significant detrimental changes in learning, memory activity level, and behavior. Copyright © 1990 American Neurological Association
引用
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页码:24 / 32
页数:9
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