INTRAVENOUS EXTENDED INFUSION OF RECOMBINANT HUMAN SOLUBLE THROMBOMODULIN PREVENTED TISSUE FACTOR-INDUCED DISSEMINATED INTRAVASCULAR COAGULATION IN RATS

被引：34

作者：

MOHRI, M

OKA, M

AOKI, Y

GONDA, Y

HIRATA, S

GOMI, K

KIYOTA, T

SUGIHARA, T

YAMAMOTO, S

ISHIDA, T

MARUYAMA, I

机构：

[1] KAGOSHIMA UNIV,SCH MED,DEPT CLIN LAB MED,KAGOSHIMA 890,JAPAN

[2] ASAHI CHEM IND CO LTD,INST LIFE SCI RES,FUJI,SHIZUOKA,JAPAN

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1994年 / 45卷 / 04期

关键词：

RECOMBINANT HUMAN SOLUBLE THROMBOMODULIN; DIC; TF; ANIMAL MODEL;

D O I：

10.1002/ajh.2830450406

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study demonstrated that intravenous infusion of recombinant human soluble thrombomodulin (rhs-TM) could inhibit disseminated intravascular coagulation (DIC) caused by 4 hr infusion of tissue factor (TF) in rats. Extended infusion of TF reduced fibrinogen and platelet counts and elevated serum FDP lever. Pretreatment and coinfusion of rhs-TM could block changes of these DIC-parameters without prolongation of APTT. Heparin, which is a potent anti-DIC drug, could also inhibit these changes with extra prolongation of APTT and PT. Thus, these results suggest thrombomodulin prevent DIC less bleeding tendency than heparin. (C) 1994 Wiley-Liss, Inc.

引用

页码：298 / 303

页数：6

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HIRATA, S ;

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AOKI, Y ;

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SUGIHARA, T ;

KIYOTA, T ;

YAMAMOTO, S ;

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