THE MECHANISM OF CYTOCHROME-P-450 DEPENDENT C-C BOND-CLEAVAGE - STUDIES ON 17-ALPHA-HYDROXYLASE-17,20-LYASE

被引：37

作者：

CORINA, DL ^{[1
]}

MILLER, SL ^{[1
]}

WRIGHT, JN ^{[1
]}

AKHTAR, M ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,SCH BIOL SCI,DEPT BIOCHEM,SOUTHAMPTON SO9 3TU,HANTS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 11期

关键词：

D O I：

10.1039/c39910000782

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It is shown that formation of 17-alpha-hydroxyandrost-5-en-3-beta-ol from pregnenolone occurs solely at the expense of the cleavage of the C-17-C-20 bond of the precursor and is best rationalised by invoking the participation of an Fe(III)-OOH intermediate in the acyl-carbon fission process.

引用

页码：782 / 783

页数：2

共 14 条

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