ANGIOTENSIN-INDUCED GROWTH RELATED METABOLISM IS ACTIVATED IN CULTURED SMOOTH-MUSCLE CELLS FROM SPONTANEOUSLY HYPERTENSIVE RATS AND WISTAR-KYOTO RATS

被引：33

作者：

SCOTTBURDEN, T ^{[1
]}

RESINK, TJ ^{[1
]}

HAHN, AWA ^{[1
]}

BUHLER, FR ^{[1
]}

机构：

[1] UNIV HOSP BASEL,DEPT RES,CH-4031 BASEL,SWITZERLAND

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 02期

关键词：

ANGIOTENSIN; VASCULAR SMOOTH MUSCLE GROWTH METABOLISM;

D O I：

10.1093/ajh/4.2.183

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Smooth muscle cells from spontaneously hypertensive rats (SHR) proliferate in culture faster than those isolated from sex- and age-matched Wistar-Kyoto (WKY) animals. There was no difference in the kinetics of S6 kinase activation in the two cultures, but later metabolic events associated with proliferation were stimulated earlier in SHR cells than in WKY, eg, activation of ornithine decarboxylase. Both cell types elaborated an extensive extracellular matrix in culture composed of a different blend of connective tissue macromolecules. Matrix material from SHR cells was more stimulatory to growth of WKY cultures than their own matrices. Angiotensin stimulated the growth and synthesis of extra-cellular matrix material in SHR more than in WKY derived vascular smooth muscle cell cultures.

引用

页码：183 / 188

页数：6

共 39 条

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