THE FUNCTION OF S1' SUBSITE POCKET OF CARBOXYPEPTIDASE-A

被引：9

作者：

KIM, DH

KIM, KB

机构：

[1] Department of Chemistry, Pohang Institute of Science and Technology, Pohang, 790-600

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 06期

关键词：

INHIBITORS; COMPLEX;

D O I：

10.1016/S0960-894X(01)80817-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Our study on the mechanism involved in the substrate recognition of Carboxypeptidase A using transition state analog inhibitors indicated that, on the contrary to the general believe, there is no hydrophobic interaction involved. The bulky hydrophobic moiety entered the narrow opening of the subsite pocket is held by Tyr-248 which moved from the enzyme surface until the catalytic action is over.

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页码：323 / 326

页数：4

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