EFFECT OF COCAINE AND COCAINE METABOLITES ON CEREBRAL-ARTERIES INVITRO

被引：135

作者：

MADDEN, JA

POWERS, RH

机构：

[1] MED COLL WISCONSIN,DEPT NEUROL,MILWAUKEE,WI 53295

[2] MED COLL WISCONSIN,DEPT PATHOL,MILWAUKEE,WI 53295

来源：

LIFE SCIENCES | 1990年 / 47卷 / 13期

关键词：

D O I：

10.1016/0024-3205(90)90169-R

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cocaine has pronounced peripheral vasoconstrictor effects. Despite the short half life of cocaine in the body these effects are relatively long-lived. The role of cocaine metabolites in vasoconstriction attributed to cocaine has not been reported. We evaluated the contractile ability of cocaine and its major metabolites in isolated cat cerebral arteries. The primary cocaine metabolite, benzollecgonine was a potent contractile agent, causing a 50% decrease in cross sectional area at 10-5 M. This was less than caused by serotonin, but greater than caused by norepinehrine. Ecgonine and cocaine were less active contractile agents than was benzoylecgonine, and ecgonine methyl ester was a mild relaxant. © 1990.

引用

页码：1109 / 1114

页数：6

共 21 条

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