LIQUID-CHROMATOGRAPHIC ANALYSIS OF REGIOISOMERS AND ENANTIOMERS OF N-(CHLOROBENZYL)-ALPHA-METHYLPHEN-ETHYLAMINES - ANALOGS OF CLOBENZOREX

被引：7

作者：

NOGGLE, FT ^{[1
]}

CLARK, CR ^{[1
]}

ANDURKAR, SV ^{[1
]}

DERUITER, J ^{[1
]}

机构：

[1] AUBURN UNIV, SCH PHARM, DEPT PHARMACEUT SCI, DIV MED CHEM, AUBURN, AL 36849 USA

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1990年 / 13卷 / 04期

关键词：

D O I：

10.1080/01483919008051819

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The regioisomeric 2-, 3- and 4-chlorobenzylamphetamines were synthesized from racemic and (+)-amphetamine by reductive alkylation. The 2-, 3- and 4-chloro regioisomers were separated by reversed-phase liquid chromatography following phenylisothiocyanate derivatization. The indiviual enantiomers of each regioisomer were identified by HPLC following derivatization with GITC. Normal phase liquid chromatographic analysis of the diastereomeric GITC derivatives produced a-values of approximately 1.0 for each racemic pair of regioisomers. These methods were developed in order to specifically identify the drug clobenzorex, d-N-(2-chlorobenzyl)-ar-methylphenethylamine and distinguish it from its optical and regioisomers. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：763 / 777

页数：15

共 14 条

[11] LIQUID-CHROMATOGRAPHIC AND MASS-SPECTRAL ANALYSIS OF N-SUBSTITUTED ANALOGS OF 4-METHOXYAMPHETAMINE
NOGGLE, FT
CLARK, CR
MCMILLIAN, CL
DERUITER, J
[J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1989, 27 (10) : 607 - 611
[12] NOGGLE FT, IN PRESS J CHROMATOG
[13] IMPROVED CHIRAL DERIVATIZING AGENTS FOR THE CHROMATOGRAPHIC RESOLUTION OF RACEMIC PRIMARY AMINES
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SIMMONS, KA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (15) : 2520 - 2527
[14] WAINER IW, 1984, LIQ CHROMATOGR MAG, V2, P88

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