ATP-SENSITIVE K+ CHANNEL ACTIVATORS SUPPRESS THE GABAERGIC INHIBITORY TRANSMISSION BY ACTING ON BOTH PRESYNAPTIC AND POSTSYNAPTIC SITES IN RAT CULTURED HIPPOCAMPAL-NEURONS

被引：26

作者：

OHNOSHOSAKU, T

SAWADA, S

YAMAMOTO, C

机构：

[1] Department of Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa

来源：

NEUROSCIENCE LETTERS | 1993年 / 159卷 / 1-2期

关键词：

ATP-SENSITIVE K+ CHANNEL; K+ CHANNEL; INHIBITORY TRANSMISSION; GABA; HIPPOCAMPUS; DIAZOXIDE; CROMAKALIM;

D O I：

10.1016/0304-3940(93)90818-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of ATP-sensitive K+ (K(ATP)) channel activators on the inhibitory transmission were explored by applying the patch-clamp technique to both presynaptic and postsynaptic hippocampal neurons prepared from neonatal rats. Diazoxide (0.5 mM) and cromakalim (0.5 mM) reduced GABAergic synaptic currents to 57 and 81% of control, respectively, and reduced the currents induced by exogenously applied GABA (10 muM) to 74 and 95% of control, respectively. These results suggest that K(ATP) channel activators suppress the GABAergic transmission partly by reducing the GABA release and partly by affecting the postsynaptic GABA response.

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收藏

页码：139 / 142

页数：4

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