PERSISTENT B19 PARVOVIRUS INFECTIONS IN HEMOPHILIC HIV-1-INFECTED PATIENTS

被引:30
作者
MUSIANI, M [1 ]
ZERBINI, M [1 ]
GENTILOMI, G [1 ]
RODORIGO, G [1 ]
DEROSA, V [1 ]
GIBELLINI, D [1 ]
VENTUROLI, S [1 ]
GALLINELLA, G [1 ]
机构
[1] UNIV BOLOGNA, DEPT ANGIOL & BLOOD COAGULAT, I-40138 BOLOGNA, ITALY
关键词
HEMOPHILIC PATIENTS; HIV INFECTION; B19;
D O I
10.1002/jmv.1890460204
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
B19 infection can be acquired by transmission with blood factors in patients with congenital bleeding disorders, requiring clotting factor concentrates. In immunodeficient patients, the failure of immunity to clear B19 virus may produce persistent infections. The presence of B19 DNA in blood samples from seven haemophilic patients with concomitant HIV-1 infection was studied over a period of three-to-four years. Dot blot hybridization assays with DNA and RNA probes were used to detect medium high viremias, and polymerase chain reaction (PCR) to detect very low viremic titres. Three patients were negative for B19 DNA in all the blood samples, while four patients were persistently positive for B19 DNA. Viral persistence, which in one patient was detected throughout the study period (40 months), occurred at low titre in all four positive patients with some recurrent increases in viral titre. In the four patients persistently positive for B19 DNA, acute or chronic clinical symptoms and signs that could be associated with B19 were not noted when virus was present at low titre (B19 DNA detectable only by PCR). When patients had a higher viral titre (B19 DNA detectable by dot blot hybridization) acute manifestations (aplastic crisis, Fifth disease, fevers, pneumonitis) were found. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:103 / 108
页数:6
相关论文
共 31 条
[1]   DETECTION OF ANTIBODIES AND ANTIGENS OF HUMAN PARVOVIRUS B19 BY ENZYME-LINKED-IMMUNOSORBENT-ASSAY [J].
ANDERSON, LJ ;
TSOU, C ;
PARKER, RA ;
CHORBA, TL ;
WULFF, H ;
TATTERSALL, P ;
MORTIMER, PP .
JOURNAL OF CLINICAL MICROBIOLOGY, 1986, 24 (04) :522-526
[2]   HUMAN PARVOVIRUSES [J].
ANDERSON, LJ .
JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (04) :603-608
[3]   HUMAN PARVOVIRUS-B19 AND PREGNANCY [J].
ANDERSON, LJ ;
HURWITZ, ES .
CLINICS IN PERINATOLOGY, 1988, 15 (02) :273-286
[4]   HUMAN PARVOVIRUS-B19 INFECTION IN HEMOPHILIACS 1ST INFUSED WITH 2 HIGH-PURITY, VIRALLY ATTENUATED FACTOR-VIII CONCENTRATES [J].
AZZI, A ;
CIAPPI, S ;
ZAKVRZEWSKA, K ;
MORFINI, M ;
MARIANI, G ;
MANNUCCI, PM .
AMERICAN JOURNAL OF HEMATOLOGY, 1992, 39 (03) :228-230
[5]   DETECTION OF B19-PARVOVIRUS INFECTIONS BY A DOT BLOT HYBRIDIZATION ASSAY USING A DIGOXIGENIN-LABELED PROBE [J].
AZZI, A ;
ZAKRZEWSKA, K ;
GENTILOMI, G ;
MUSIANI, M ;
ZERBINI, M .
JOURNAL OF VIROLOGICAL METHODS, 1990, 27 (02) :125-133
[6]  
CASSINOTTI P, 1993, 5TH PARV WORKSH CRYS, P76
[7]   CASE-REPORT - ELECTRON-MICROSCOPIC DETECTION OF HUMAN PARVOVIRUS (B19) IN A PATIENT WITH HIV-INFECTION [J].
CHRYSTIE, IL ;
ALMEIDA, JD ;
WELCH, J .
JOURNAL OF MEDICAL VIROLOGY, 1990, 30 (04) :249-252
[8]   DIAGNOSTIC ASSAYS WITH MONOCLONAL-ANTIBODIES FOR THE HUMAN-SERUM PARVOVIRUS-LIKE VIRUS (SPLV) [J].
COHEN, BJ ;
MORTIMER, PP ;
PEREIRA, MS .
JOURNAL OF HYGIENE, 1983, 91 (01) :113-&
[9]   PARVOVIRUS B19 SPECIFIC DNA IN BONE-MARROW FROM B19 ARTHROPATHY PATIENTS - EVIDENCE FOR B19 VIRUS PERSISTENCE [J].
FOTO, F ;
SAAG, KG ;
SCHAROSCH, LL ;
HOWARD, EJ ;
NAIDES, SJ .
JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (03) :744-748
[10]   PERSISTENT B19 PARVOVIRUS INFECTION IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) - A TREATABLE CAUSE OF ANEMIA IN AIDS [J].
FRICKHOFEN, N ;
ABKOWITZ, JL ;
SAFFORD, M ;
BERRY, JM ;
ANTUNEZDEMAYOLO, J ;
ASTROW, A ;
COHEN, R ;
HALPERIN, I ;
KING, L ;
MINTZER, D ;
COHEN, B ;
YOUNG, NS .
ANNALS OF INTERNAL MEDICINE, 1990, 113 (12) :926-933