NITRIC-OXIDE AS MEDIATOR OF THE GASTROPROTECTION BY CHOLECYSTOKININ-8 AND PENTAGASTRIN

被引：27

作者：

STROFF, T ^{[1
]}

LAMBRECHT, N ^{[1
]}

PESKAR, BM ^{[1
]}

机构：

[1] RUHR UNIV BOCHUM,DEPT EXPTL CLIN MED,D-44780 BOCHUM,GERMANY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 260卷 / 01期

关键词：

CHOLECYSTOKININ-8; PENTAGASTRIN; NITRIC OXIDE (NO);

D O I：

10.1016/0014-2999(94)90019-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cholecystokinin-8 and pentagastrin protect against ethanol-induced gastric mucosal lesions in rats. The protective effect is antagonized by the nitric oxide (NO) synthase inhibitor, N-G-nitro-L-arginine, The inhibitory action of N-G-nitro-L-arginine is reversed by L-arginine, but not D-arginine. The findings suggest that NO is involved in the gastroprotection induced by both peptides.

引用

页码：R1 / R2

页数：2

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