STRUCTURE AND EXPRESSION OF THE HUMAN TRITHORAX-LIKE GENE-1 INVOLVED IN ACUTE LEUKEMIAS

被引：42

作者：

PARRY, P ^{[1
]}

DJABALI, M ^{[1
]}

BOWER, M ^{[1
]}

KHRISTICH, J ^{[1
]}

WATERMAN, M ^{[1
]}

GIBBONS, B ^{[1
]}

YOUNG, BD ^{[1
]}

EVANS, G ^{[1
]}

机构：

[1] ST BARTHOLOMEWS HOSP,IMPERIAL CANC RES FUND,DEPT MED ONCOL,LONDON EC1A 7BE,ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 10期

关键词：

D O I：

10.1073/pnas.90.10.4738

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human trithorax-like gene 1 (Htrx1 gene) is disrupted in 11q23 translocations that are associated with acute leukemias. Sequencing of a partial human cDNA revealed an open reading frame encoding 1012 amino acids with extensive homology to the Drosophila trithorax protein, particularly in the zinc finger-like domains. Htrx1 gene appears to be unique in the human genome and has been conserved during evolution. Use of the human cDNA as a probe demonstrates that this gene is interrupted in both infant and adult acute myeloid (AML) and lymphoid (ALL) leukemia patients with 11q23 translocations. The structure of the Htrx1 gene around the breakpoints shows that this part of the human gene is interrupted by nine introns. As a result of the rearrangement, zinc finger domains are translocated in both ALL and AML patients. Expression studies reveal that the Htrx1 gene differentially expresses three transcripts within the normal lymphocyte cell lineage.

引用

页码：4738 / 4742

页数：5

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