NONSTRUCTURAL PROTEINS OF AUTONOMOUS PARVOVIRUSES - FROM CELLULAR EFFECTS TO MOLECULAR MECHANISMS

被引：42

作者：

VANACKER, JM

ROMMELAERE, J

机构：

[1] Laboratory of Tumor Virology, Deutsches Krebsforschungszentrum, P.101949, D-69009, Heidelberg, Abt. 0610/INSERM U 375

来源：

SEMINARS IN VIROLOGY | 1995年 / 6卷 / 05期

关键词：

AUTONOMOUS PARVOVIRUSES; CYTOTOXICITY; NONSTRUCTURAL PROTEINS; ONCOLYSIS;

D O I：

10.1006/smvy.1995.0035

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Parvovirus toxicity is characterized by its remarkable specificity for defined target cells, in particular some neoplastic cells. The production and activity of the parvoviral non-structural (NS) proteins appear responsible for at least part of this effect. Recent molecular analyses of NS proteins regarding the control of DNA replication and gene expression haw begun to provide insights as to possible mechanisms of parvovirus cytotoxicity.

引用

页码：291 / 297

页数：7

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